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What is the use of LncRNA2Target database

2025-01-28 Update From: SLTechnology News&Howtos shulou NAV: SLTechnology News&Howtos > Internet Technology >

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This article mainly introduces the use of LncRNA2Target database, the article is very detailed, has a certain reference value, interested friends must read it!

LncRNA plays an important role in the regulation of gene expression. There are two research strategies to study the target genes regulated by lncRNA. One is to analyze the proteins bound by lncRNA through traditional experimental methods to determine the interaction between lncRNA and protein-coding genes. The common methods are as follows

Immunoprecipitation assays

RNA pull down assays

Luciferase reported assays

Another method is to knock down or over-express a lncRNA, and then detect the differentially expressed genes before and after treatment, and take the differentially expressed genes as the target genes of the lncRNA, either by chip or high-throughput sequencing.

The LncRNA2Target database collates the published lncRNA target gene data, the latest version is v2.0, and the website is as follows

Http://123.59.132.21/lncrna2target/index.jsp

The lncRNA target genes in humans and mice are covered. The corresponding results can be viewed through the Browse menu, as shown below.

Through the Search menu, you can easily retrieve the database, as shown below

The database provides download function and provides lncRNA target gene files analyzed by traditional experiments and high-throughput methods, respectively, corresponding to the following two files

LncRNA_target_from_low_throughput_experiments.xlsx

LncRNA_target_from_high_throughput_experiments.txt

For high-throughput data, the corresponding GEO number, the expression spectrum data and the results of difference analysis are also given, as shown below.

Through this database, we can not only query the target gene information of lncRNA, but also learn the idea of studying lncRNA target gene.

The above is all the contents of the article "what is the use of LncRNA2Target database". Thank you for reading! Hope to share the content to help you, more related knowledge, welcome to follow the industry information channel!

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