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This article mainly shows you "what is NCG database", the content is easy to understand, clear, hope to help you solve your doubts, the following let the editor lead you to study and learn "what is NCG database" this article.

The identification of driving genes is an important part of tumor genomics research. NCG is a database of tumor driving genes. The latest version is v6.0.

Http://ncg.kcl.ac.uk/index.php

A total of 2372 driving genes are included, which are divided into the following two parts

711 Known cancer genes

1661 Candidate cancer genes

For each gene, a variety of annotation information is provided, taking PTEN as an example, including the following parts of annotation information

1. General information

Provides links to genes in NCBI, Ensembl, Uniprot and other databases, as well as protein domain SMART, somatic mutation COSMC, related disease OMIM and other databases, as shown below

2. Cancer Information

The tumor information related to the gene is provided, which is viewed in the form of a link between the COSMIC database and the corresponding pubmed literature, as shown below.

3. Orthology

The homologous information of the gene among different species is provided, as shown below.

4. Gene Expression in Normal Tissues

Provides information on gene expression from the following two databases

GTEx

HPA

5. Protein Expression in Normal Tissues

The protein expression information from the HPA database is provided, and the results are as follows

6. Protein Function

Functional annotations from the following three databases are provided

KEGG

Reactome

BioCarta

The results are as follows

7. Duplicablity

The homologous region of the gene in the genome was identified by blat alignment. The results are as follows.

8. Network Properties

The interaction network between this gene and other genes is provided by using the databases of BioGRID, MIntAct, DIP, HPRD and Reactome, which is composed of protein interaction and protein complex. The results are as follows.

9. Gene Expression in Cancer Cell Lines

The information of gene expression from CCLE database is provided, and the results are shown below.

10. Gene Essentiality

The importance of genes is scored by PICKLES and OGEE database, and the results are as follows

11. MiRNA-Gene interactions

The regulatory network of this gene and miRNA is provided by using the information of miRNA target gene in miRTarBase and miRecords database. The results are as follows.

Through this database, the driving genes of tumors can be quickly searched, and various annotation information of genes can be viewed and analyzed.

The above is all the contents of this article "what is the database of NCG?" Thank you for reading! I believe we all have a certain understanding, hope to share the content to help you, if you want to learn more knowledge, welcome to follow the industry information channel!

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