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China's first medical magnesium alloy bone screw enters clinical trial: biodegradable without second surgical removal

2025-04-05 Update From: SLTechnology News&Howtos shulou NAV: SLTechnology News&Howtos > IT Information >

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Shulou(Shulou.com)11/24 Report--

CTOnews.com, November 5 (Xinhua)-- the 3D Printing Innovation Research Center of the Ninth people's Hospital affiliated to the Medical College of Shanghai Jiaotong University recently announced the launch of a clinical trial of a new biodegradable coated magnesium alloy bone screw. This material is regarded as a "new generation of revolutionary metal biomaterials", which is expected to completely change the current internal fixation technology based on stainless steel and titanium alloy, and avoid the pain and risk of patients' second operation.

According to CTOnews.com, fracture is a common trauma. At present, surgical treatment of fracture has a history of more than 100 years. Only two kinds of materials, stainless steel and titanium alloy, have been successfully used in steel plates, screws and other instruments. However, the hardness of the former is too strong, easy to cause osteoporosis; the latter will also affect the follow-up imaging examination of patients. Most importantly, these materials need to be removed by a second operation after fracture healing, causing damage to the patient and the tissue around the injury.

In order to solve these problems, Shanghai Jiaotong University, Ninth Hospital and Shanghai Chuang Medical Technology (Shanghai) Co., Ltd. have jointly developed a biodegradable coated magnesium alloy bone screw. Magnesium is an essential trace element for human body, which plays an important role in the growth and metabolism of bone. The product achieves a good balance in biocompatibility, toughness and controllable degradation, and can meet the needs of patients, thus avoiding the needs of patients for secondary surgery. This technology is currently in the leading domestic and international stage, and is known as "a new generation of revolutionary metal biomaterials".

It is reported that the product has passed the big animal experiment and achieved good results. At present, the product has entered the clinical trial stage, and prospective, multicenter, randomized, single-blind, parallel controlled studies will be conducted in many hospitals to evaluate its safety and effectiveness. This product is mainly suitable for internal fixation of fractures in non-critical load-bearing parts, such as hands, feet, ribs and so on. It is estimated that the product will be degraded by 50% within one year, and will be basically degraded within 3 to 5 years, without the need for a second operation.

Dai Zirong, academician of the Chinese Academy of Engineering and leader of the orthopaedics department of the Ninth Academy of Engineering, commented that this technology is currently in the domestic leading and international stage. "in addition to its application in the field of orthopaedics, there are more products such as cardiac stents that can also benefit from this material, covering sports medicine, thoracic surgery, general surgery and other fields."

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