Shulou(Shulou.com)11/24 Report--

Thanks to CTOnews.com netizens for the clue delivery of the holy Buddha! This article comes from the official account of Wechat: SF Chinese (ID:kexuejiaodian), author: SF

(photo Source: Pexels) as they get older, many people feel that their memory is getting worse and that they are learning new things more and more slowly. This is a normal physiological phenomenon, along with the aging of the brain, will lead to memory loss, learning ability decline, attention decline phenomenon. Serious diseases such as Alzheimer's disease and Parkinson's disease will occur in old age. More worryingly, the onset age of these neurodegenerative diseases is getting younger and lower.

(by Mei Lin / tr. by Robert Taylor)

To this end, many middle-aged partners begin to worry about whether they are at risk of developing neurodegenerative diseases. As a result, many people have started thinking training to prevent "dementia" according to the "secret" on social media. Some partners choose "diet therapy", from walnuts to various vitamins, including some supplements that are popular in major media. Have become their weapons against brain aging.

In some European and American countries, the trend of exchange transfusion and anti-aging emerged more than ten years ago. In April, American tycoon Bryan Johnson began to change blood with his 17-year-old son. After holding on for 3 months, Johnson found that the change of blood transfusion had no effect and announced that he would stop the attempt.

In fact, as early as 2016, the US Food and Drug Administration (FDA) issued a statement discouraging the use of blood exchange to fight aging. Because there is no research to prove that replacing plasma with young people can fight against aging. Now, things have changed.

Is blood exchange really effective in anti-aging? Recently, a team led by Professor Saul Villeda of the University of California, San Francisco, found that injecting plasma from young individuals into older individuals does "reverse" aging.

So which component in plasma plays a role in reversing aging? This aroused the interest of Villeda's team. Through comparative experiments, they found that the content of chemokine PF4 in the plasma of young individuals was much higher than that of old individuals. It may be that this factor plays a role in reversing aging, so the team injected exogenous PF4 factor into mice and found that PF4 factor can improve hippocampal nerve inflammation, which is related to age.

After further analysis, the scientists believe that PF4 can inhibit the overactivation of the immune system in the body and brain, reduce the level of anti-aging immune factors, and repair the aging peripheral immune system. These effects can eventually promote the individual's cognitive ability to return to the level of youth. As Professor Villeda said: "in the experiment, we used mice in their 70s, and PF4 restored their brains to the human age of 30 or 40."

How does the longevity factor work? Klotho is a gene in human cells, and previous studies have found that it is associated with human lifespan. Not only that, the protein expressed by Klotho gene also has the effect of reversing brain aging. In previous research, Dena Dubal, also a professor at the University of California, San Francisco, has determined that Klotho protein can improve the cognitive ability of older animals and help them resist aging-related brain diseases.

However, Dubar also found that foreign Klotho proteins artificially injected into experimental animals could not pass through the blood-brain barrier, meaning that this longevity factor could not reach the brain at all, so how does it work? In the latest study by Dubar's team, scientists found that the Klotho protein works by activating PF4.

Exercise can prevent and treat neurodegenerative diseases on social media, many healthy KOL claim that exercise has one benefit or another. From losing weight to lowering blood sugar, from preventing depression to improving cardiopulmonary function, from helping sleep to improving body resistance, it seems that exercise has become the universal patron saint of health. So how much of this is true or false? It is estimated that the majority of netizens and partners who have eaten too much have lost confidence in this kind of propaganda.

In fact, we don't have to scoff at the efficacy of exercise. Recently, a team led by Professor Tara Walker of the University of Queensland in Australia found that exercise plays an important role in reversing brain aging.

Through experiments in mice, Walker's team found that mice after exercise had higher levels of PF4. Further analysis showed that after exercise, mouse platelets released PF4 into the bloodstream. This may be due to the damage of some tiny blood vessels caused by exercise, and the role of PF4 is to inhibit the activity of antithrombin and promote healing.

All three studies, published in Nature and its sub-journals, have proved that PF4 can reverse brain aging and prevent neurodegenerative diseases from different angles.

References:

Https://doi.org/10.1038/s41586-023-06436-3

Https://doi.org/10.1038/s43587-023-00468-0

Https://doi.org/10.1038/s41467-023-39873-9

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