Shulou(Shulou.com)11/24 Report--

Thanks to CTOnews.com netizens Cainiao N, glittering C.C., soft media users 1520111 clue delivery! CTOnews.com, August 3 (Xinhua)-- the American Cancer Research Agency wants City of Hope to issue a statement saying that its scientists are developing a "targeted chemotherapeutic drug (AOH1996) that can kill all solid malignant tumors." it is currently in phase 1 clinical trials.

City of Hope wrote in an official press release that AOH1996 has achieved some results in preclinical studies for the treatment of breast, prostate, brain, ovarian, cervical, skin and lung cancer cells. AOH1996 can be taken orally and its metabolism is stable. It can inhibit tumor growth either as a single treatment or as a combination therapy, but does not cause perceptible side effects.

CTOnews.com learned from the City of Hope website that AOH1996 is an oral small molecule PCNA (proliferating cell nuclear antigen) inhibitor used to inhibit the proliferation of tumor cells. According to reports of pre-clinical studies, researchers tested AOH1996 in more than 70 cancer cell lines and several groups of normal cells. This research therapy prevents cells with damaged DNA from dividing in G2 / M phase and prevents incorrect DNA replication in S phase. The end result is that AOH1996 causes cancer cell death (apoptosis) without interrupting the reproductive cycle of healthy stem cells.

The left side of the ▲ is untreated cancer cells, and on the right is the cancer cells after using AOH1996 (image source City of Hope). "PCNA is like a terminal hub with multiple boarding gates," the researchers said. The fact that data show that PCNA has unique changes in cancer cells enables us to design a drug that targets only the form of PCNA in cancer cells. Our cancer kill pill is like a snowstorm, shutting down a key aviation hub and shutting down all incoming and outgoing flights. "

At present, this study has entered the phase 1 clinical trial, which mainly studies people's tolerance to new drugs and puts forward a preliminary, safe and effective drug administration scheme to guide the next stage of clinical trials.

Drug marketing usually involves four stages of clinical trials: the first phase is one to two years, the second phase is one year, the third phase is half a year to one year, and the fourth phase is one to two years.

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