Shulou(Shulou.com)11/24 Report--

CTOnews.com, May 7, the Zhou Xin team of researchers from the Institute of Precision Measurement Science and Technology Innovation of the Chinese Academy of Sciences developed a modular self-assembled nanoparticle GQD NT that can intelligently identify tumors by taking advantage of the difference between tumor microenvironment and normal tissue.

This is a kind of nanoparticles that can achieve accurate detection and treatment of cancer, which can significantly reduce the side effects of overuse of drugs in cancer detection and treatment. CTOnews.com note, the relevant research results have recently been published in the international well-known academic journal Advanced Materials (DOI:10.1002/adma.202211337).

By constantly deforming in the tumor, this kind of nanoparticles can prolong the residence time of the drug in the tumor and enhance the penetration of the drug in the tumor. the long-term magnetic resonance imaging detection and efficient treatment of cancer photodynamic therapy were realized with very low drug dose.

To put it simply, drug overdose is the main cause of side effects in cancer detection and treatment of Pixabay. This is because the existing drugs are not enough to target the focus, it is difficult to enrich in the tumor area, and the residence time in the focus site is short, so high-dose injection is needed to achieve the desired imaging detection and treatment effect.

Photodynamic therapy (PDT) mentioned here is a new treatment for cancer, because the photosensitizer (PSs) used is active and toxic only when exposed to light, and has a high space-time selectivity. In order to maximize its efficacy, it is usually necessary to repeatedly use PDT to ablate a variety of tumors. However, due to the continuous injection of PSs, the total dose is too high, which will cause serious side effects. Therefore, researchers have developed a graphene quantum dot nanoconverter (GQD NT) based on acidity activation as a carrier for long-term tumor imaging and repetitive PDT.

Under the guidance of Arg-Gly-Asp peptide, GQD NT can actively target tumor tissue, and then relax and increase in tumor acidity, which is expected to remain in the tumor for a long time. The GQD NT then breaks down into small pieces and penetrates into the tumor in a better way.

Under laser irradiation, GQD NT produces a mild hyperthermic effect, which increases the permeability of cell membrane and promotes the uptake of PSs. The most breakthrough is that the prepared GQD NT not only "turns on" the fluorescence / magnetic resonance signal, but also achieves efficient repetition of PDT.

Overall, the study developed an intelligent vector that enhanced the accumulation, retention and release of PSs in tumors through programming deformations, thus overcoming the barrier of over-injection in repetitive PDT.

Image source Pexels said that GQD NT can use very simple steps to encapsulate drug molecules in it, promote GQD NT deformation through the tumor microenvironment, and gradually increase the concentration of the drug in the focus. Mouse experiments have found that the amount of contrast agent used by GQD NT in cancer detection is only 6% to 22% of that of existing clinical techniques. Within 4 to 36 hours after injection, the contrast agent at the tumor site had a high contrast with normal tissue, and the boundary was obvious, which greatly prolonged the time of magnetic resonance imaging.

Based on the photodynamic therapy designed by GQD NT, the tumor volume decreased by 82% after a single photodynamic therapy, and the tumor was ablated completely after twice photodynamic therapy.

In the experiment, the total dose of photosensitive drugs was reduced to a very low level of 1.76 to 3.50 micromoles / kg, which was reduced by 90% (single treatment) to 95% (twice) compared with that reported in the literature, and the low dose laser used did not cause skin damage. it is expected to overcome the problem of photosensitive drug overdose in photodynamic therapy.

Welcome to subscribe "Shulou Technology Information " to get latest news, interesting things and hot topics in the IT industry, and controls the hottest and latest Internet news, technology news and IT industry trends.