Shulou(Shulou.com)11/24 Report--

CTOnews.com, February 19, according to the official news of Shanghai Children's Medical Center, recently National Children's Medical Center (Shanghai), Fu Wei and Wang Wei of Shanghai Children's Medical Center affiliated to Shanghai Jiaotong University School of Medicine, together with the team of Professor you Zhengwei of Donghua University, published the research results entitled "Intrinsically Cryopreservable Bacteriostatic Durable Glycerohydrogel Inks for 3D Bioprinting" (bacteriostatic 3D bio-printing glycerol hydrogel ink that can be cryopreserved directly) in the authoritative journal Matter (IF=19.967). In this paper, the concept of using glycerol to regulate the state of "free water" to synthesize glycerol hydrogel biological ink is proposed for the first time. It is proved that the biological ink has a series of characteristics, such as bacteriostasis, shape fidelity, suitable for 3D biological printing and cell cryopreservation protection, and has a wide biomedical application prospect.

CTOnews.com learned that 3D biological printing can produce 3D tissue models with different shapes and different cellular components, so it plays a more and more important role in biomedical applications, and is widely used in regenerative medicine, disease modeling, drug screening and other fields. Biological ink is the key to realize 3D biological printing. Hydrogel has become one of the commonly used biological ink materials because of its excellent biocompatibility and the ability to simulate extracellular matrix. In the past, the research on hydrogel biological ink mainly focused on the cytocompatibility and cell survival rate of tissue after 3D biological printing. In addition, ordinary hydrogel biological ink objectively provides a moist and closed environment for bacterial reproduction, and the water it contains is easy to evaporate. At present, 3D biological printing still faces the following challenges: (1) the bacteriostatic ability of biological ink is poor; (2) the long-term shape fidelity of 3D printing tissue is difficult; (3) the cryopreservation effect of 3D printing tissue is not good. Therefore, for the practical application of biological printing, there is an urgent need to establish a new biological ink system.

Shanghai Children's Medical Center and Donghua University have developed a multi-functional glycerol hydrogel as biological ink to solve the above problems one by one. The key step is to use glycerol to adjust the state of "water" in biological ink. The limited "free water" in glycerol hydrogel is not conducive to bacterial reproduction and can significantly inhibit the growth of Escherichia coli and mold. The glycerol hydrogel scaffold prepared by 3D printing can also maintain the shape fidelity by inhibiting the evaporation of "water", and the cells in the glycerol hydrogel show higher activity than those in the ordinary hydrogel. In addition, because most of the water in the glycerol hydrogel is bound together, thereby inhibiting crystallization, the printed tissue can be cryopreserved directly without adding cryoprotectants. Compared with the existing biological ink based on hydrogel, glycerol hydrogel biological ink has more advantages and undoubtedly has a broader prospect in the field of biomedical application.

Fu Wei, an associate researcher at the Institute of Pediatric Translational Medicine at Shanghai Children's Medical Center, said that this study has a good prospect of transformation and application, and the biological ink can be used for in vitro biological printing of a variety of tissues and organs in the future. In addition, because the hydrogel system has the functions of antibacterial, morphology maintenance and cell protection, it can also be used for cell therapy in vivo to help improve the cell retention rate and play a better role in the treatment.

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