Shulou(Shulou.com)11/24 Report--

Thanks to CTOnews.com netizen Mo_Onster for the clue delivery! CTOnews.com, October 5, Beijing time, the Royal Swedish Academy of Sciences announced that the 2022 Nobel Prize in Chemistry will be awarded to American scientist Carolyn R. Bertozzi, Danish scientist Morten P. Meldal and American scientist K. Barry Sharpless for their contributions to click chemistry and bioorthogonal chemistry. It can be used to make cancer drugs, make DNA maps and create materials suitable for specific uses. The prize for the 2022 Nobel Prize will be 10 million Swedish kronor (about 6.51 million yuan), which will be shared equally among the three. The prize will be awarded on December 10th. The money comes from the legacy of Alfred Nobel, the Swedish inventor who founded the prize in 1895.

Carolyn R. Bertozzi is a pioneer and top scientist in the field of chemical biology and sugar science in the United States. She coined the term "biological orthogonal chemistry" to summarize chemical coupling reactions that can occur without interference in living cells. Its pioneering work has assisted the process of basic drug discovery related to cancer, inflammation, bacterial infections and other diseases.

Morten Meldal is a Danish organic chemist and is currently a professor at the University of Copenhagen, focusing on combinatorial chemistry and polypeptide chemistry. In addition, Professor Meldal is also known for copper-catalyzed azide and alkyne cycloaddition reactions (CuAAC Reaction) as co-developers of click chemistry (Click chemistry) for key reactions.

K. Barry Sharpless is an American scientist who introduced the synthetic concept of click chemistry (Click chemistry) in 2001. it is characterized by good stereoselectivity, high yield, few side reactions and rapid completion of reactions, especially the derivation of biomolecules in aqueous system, which can be used in the research and development of medical diagnostic reagents and new drug development. it is considered to be a very ideal technology and has been used in drug development. In 2001, he shared the Nobel Prize in chemistry with American scientist William S. Knowles and Japanese scientist Ryoji Noyori.

CTOnews.com learned that from 1901 to 2021, the Nobel Prize in chemistry had been awarded to 188 winners, of whom Frederick Sanger was the only one who won the Nobel Prize twice, in 1958 and 1980. As a result, a total of 187 people won the Nobel Prize in chemistry from 1901 to 2021, seven of whom were women.

Click chemistry, which is translated as "link chemistry" and "fast-matching combinatorial chemistry". It is a synthetic concept introduced by chemist K B Sharpless in 2001. the purpose is to quickly and reliably complete the chemical synthesis of various molecules through the splicing of small units. In particular, it emphasizes the development of new combinatorial chemistry methods based on carbon-heteroatom bond (C-X-C) synthesis, and with the help of these reactions (click reactions) to obtain molecular diversity simply and efficiently. The representative reaction of click chemistry is copper-catalyzed azido-alkynyl Husigen cycloaddition reaction (Copper-Catalyzed Azide-Alkyne Cycloaddition). The concept of click chemistry has made a great contribution to the field of chemical synthesis, and it has become one of the most useful and attractive synthetic ideas in many fields, such as drug development and biomedical materials.

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