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This article mainly shows you "what is the use of circ2Traits database", the content is easy to understand, clear, hope to help you solve your doubts, the following let the editor lead you to study and learn "what is the use of circ2Traits database" this article.

The research of miRNA started very early, and the literature and database related to miRNA disease are also relatively mature. As a recently emerging RNA, circRNA can bind to miRNA as miRNA sponger and play a post-transcriptional regulatory function.

Circ2Traits is a database of circular RNA-related diseases or special traits. By analyzing the interaction between circular RNA and those disease-related miRNA, the association between circular RNA and diseases is established. At the same time, in order to further analyze the regulatory pathway of circular RNA in the disease, the ceRNA regulatory network of circRNA was also constructed. The web address of the database is as follows

Http://gyanxet-beta.com/circdb/

The construction of the database depends on the following four kinds of information, and the corresponding sources are described below.

Get disease-related miRNA information from miR2disease database

The interaction between annular RNA and miRNA is obtained from the study of Memzcak et al.

Get the interaction information of miRNA-mRNA from starBase database

Get the interaction information of miRNA and lncRNA from miRCode database

At present, the official website only provides the function of data download, as shown below

The first file is the information of ceRNA regulatory network, and the content is as follows: the first category is miRNA, the second is protein coding or lncRNA transcript, the third is circular RNA, and the fourth is the name of the disease.

The second file is all the information about the ring RNA, which contains the SNP information of circRNA-miRNA and the combination area of circRNA and miRNA. It has a large number of columns and is intercepted as follows.

Through this database, the disease-related circular RNA information can be obtained. At the same time, the idea of analyzing disease-related circular RNA and the strategy of integrating circRNA,ceRNA,SNP information are worthy of reference.

The above is all the contents of the article "what is the use of circ2Traits database". Thank you for reading! I believe we all have a certain understanding, hope to share the content to help you, if you want to learn more knowledge, welcome to follow the industry information channel!

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