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This article mainly shows you "what is miRWalk database", the content is easy to understand, clear, hope to help you solve your doubts, the following let the editor lead you to study and learn "what is miRWalk database" this article.

MiRWalk is a comprehensive miRNA target gene database, which contains miRNA target gene information of human, mouse and other species. similar to mirDIP, it is also an integrated database, which integrates information from miRDB, TargetScan, miRTarBase and other databases.

Http://mirwalk.umm.uni-heidelberg.de/

The database contains the miRNA target gene information of the following five species.

Human

Mouse

Rat

Dog

Cow

The official website provides two kinds of retrieval functions.

1. Retrieve one miRNA/gene at a time

The search box is as follows

For miRNA, the ID and number in the mirBase database are supported, as well as the name miRNA family.

For Gene, support gene symbol, Entrez Id, Ensembl-ID and other formats, and input the corresponding transcript ID, such as Refseq and Ensembl database transcript ID.

The search results are as follows

The page is very simple, with only one result download function.

two。 Retrieve more than one miRNA/gene at a time

The search box is as follows

It supports the retrieval of multiple miRNA or Genes at a time, which is suitable for analyzing the target information corresponding to the differential gene/miRNA obtained by transcriptome data, and also supports retrieval according to pathways. It is suitable for directly studying the target information under a certain path from a functional point of view.

Take Genes as an example, the search results are as follows

The top drop-down list allows you to filter the results, that is, you can filter the target gene information shared in multiple databases, and you can also filter based on the location and score value of the binding region.

In addition to the derivation of the results, it also provides the visualization function of regulatory network between miRNA and target genes (Graph) and gene enrichment function (GSEA).

For Graph, the results are as follows

Yellow represents miRNA, blue represents gene, and supports export to SVG, PNG, JPG and other formats.

For GSEA, enrichment analysis supports the following functions

Reactome pathway

Kegg pathway

Gene ontology

The results are as follows

Compared with mirDIP, miRWalk provides more species, and the visualization of regulatory network and GSEA enrichment function is also very practical, but because of the small number of integrated data sets, if we only analyze the information of miRNA target genes in human, mirDIP will be more comprehensive.

The above is all the contents of this article "what is the database of miRWalk?" Thank you for reading! I believe we all have a certain understanding, hope to share the content to help you, if you want to learn more knowledge, welcome to follow the industry information channel!

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