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This article mainly shows you "what is the use of RADAR database", the content is easy to understand, clear, hope to help you solve your doubts, the following let the editor lead you to study and learn "what is the use of RADAR database" this article.

As an important post-transcriptional regulation mechanism, RNA editing is a hot topic in transcriptome research. Among the different types of RNA edits, RNA editing of A-> I is the most common, and there are many software that can be used to identify this type of RNA editing.

The RADAR database collects and collates the evidence of RNA editing sites of human, mouse, fly and other species, and annotates them manually, providing a query method based on web pages. The URL is as follows

Http://rnaedit.com/

Through the query function of the official website, it can be easily searched, as shown in the following diagram

Select the corresponding species, and then provide a variety of search conditions, you can query according to the chromosome location, you can also directly query a gene-related RNA editing site.

In this database, the following two comments are provided for the location of the RNA edit point.

The first is the characteristic region of the genome, such as 5'UTR, 3'UTR, etc., and the second is the annotation of repetitive elements. A large number of studies have found that RNA editing sites exist widely in Alu repetitive sequences. According to the characteristics of the repetitive regions where RNA editing sites are located, RADAR is divided into three characteristic regions: Alu repetitive sequences, non-Alu repetitive sequences and non-repetitive sequences.

At the same time, it also provides the conservation of RNA editing sites among species, such as querying conservative RNA editing sites between human and mouse species.

Taking the human AHR gene as an example, the query results are as follows

Click on the link corresponding to Position, you can jump to the UCSC genome browser to view a specific RNA editing site. Reference gives the corresponding literature, while Editing levels gives the expression of RNA editing sites in different tissues, as shown below.

It is helpful to study the tissue specificity of RNA editing sites. The database provides a download function, as shown below

The data of RNA editing sites of different species can be downloaded directly, and for human, the RNA editing sites of certain repetitive regions can also be downloaded separately.

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