What is the use of ONGene database

This article mainly introduces the use of ONGene database, the article is very detailed, has a certain reference value, interested friends must read it!

OnGene is a database of tumor genes. 803 tumor genes were obtained by literature search.

The website of the database is as follows

Http://ongene.bioinfo-minzhao.org/index.html

The pipeline built by the database is shown in the following figure

First of all, search with the following keywords in pubmed

Oncogene

Oncogenic

Oncoprotein

Proto-oncogene

17033 candidate articles were obtained, and then 435 articles were obtained from long non-coding RNA and oncogene. In addition, tumor-related miRNA was obtained from oncomirdb and miRCancer databases.

Based on the manual check of the above literature, 803 tumor genes supported by the literature were screened, and the following data were analyzed.

Functional annotation, which provides annotation information such as gene name, participating pathway, related diseases, etc.

Difference analysis, using the expression profile data in TCGA, to analyze the difference between tumor and normal samples.

Co-expression analysis with lncRNA, using the expression profile data in MiTranscriptome database, to analyze the co-expression between tumor genes and lncRNA.

Annotation of mutation information, using mutation information in TCGA to annotate

Through the browser menu on the front page, you can browse the relevant information about tumor genes. Take the protein coding gene MYC as an example, it contains the results of the following parts.

1. Gene information

Contains the gene name, chromosome location, corresponding pathway and disease, sequence and other information, as shown below

2. Literature

The literature and abstract information related to the gene are shown as follows

3. Expression

Show the expression information of the gene in the sample as follows

4. LncRNA

Show the lncRNA information co-expressed with the gene as follows

5. Mutation

Show the mutation information that exists on the gene, as follows

6. Homolog

Show the homologous information of this gene in other species, as shown below

The information in the database can be downloaded free of charge, with the following link

Http://ongene.bioinfo-minzhao.org/download.html

For tumor research, this database is very worthy of reference, which can help us to quickly screen candidate tumor genes.

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