Shulou(Shulou.com)06/01 Report--

Today, I will talk to you about how to analyze the KEGG Drug database, many people may not know much about it. In order to make you understand better, the editor has summarized the following contents for you. I hope you can get something according to this article.

Kegg drug database is a comprehensive database of drug-related information, including drugs listed in Japan, the United States, and Europe. All drugs listed in Japan, whether prescription or over-the-counter drugs, including natural medicines and traditional Chinese medicines, are recorded in Drug data; for drugs listed in the United States and Europe, only some of the prescription drugs are recorded in the drug database.

Drugs are distinguished according to their chemical results and chemical compositions. the drugs in the enzyme are marked with D number, such as D014441, which acts on chronic myeloid leukemia. For each drug, its general name, chemical structure, target genes, related metabolic enzymes, transporters and other information are recorded, taking D014441 as an example.

Field meaning EntryD numberName common name and registered trade name Products GenericDailyMed database link Formula molecular formula Exact mass mass Mol Weight molecular weight Structure chemical structure other molecules ClassDGROUP database defined classification Efficacy Diseasee acting disease Target Pathway drug target corresponding human gene and these target parameters Metabolism drug metabolism related enzyme Structure mappathway database Brite classification information in brite database

On the basis of structural similarity and functional similarity, a KEGG DGROUP database was established, and drugs were classified, and each group began with a DG number. In the DGROUP database, there are two types of group:

1. The first contains only the corresponding drugs, which have similar chemical structures. For example, DG00710 contains D08066 and D01441.

two。 The second group also contains the next level of group, which is actually divided into different levels according to function. For example, DG01918 contains both drugs D10223 and group DG01917.

In addition to the KEGG DGROUP database, the brite database also has classification information about drugs, but there are many criteria for classification.

In fact, many new drugs only retain the core chemical structure on the basis of existing drugs and are formed by slight changes in other groups. understanding this change in chemical structure can provide some reference for us in the field of drug development. So kegg draws the corresponding path map of the chemical structure of various drugs in the pathway database, called Structure map, and all the Structure map constitute a major category in the pathway database, called Drug Development.

The corresponding picture of map07011 is as follows

1. Drug is a comprehensive database of drug-related information, covering all drugs listed in Japan and some prescription drugs listed in the United States and Europe.

two。 According to the different chemical structure, each drug is distinguished, and each drug is uniquely identified by D-Number. The chemical structure, target genes, metabolism-related enzymes and other basic information of drugs are recorded in the database.

3. For the classification of drugs, KEGG GROUP database classifies drugs according to structural and functional similarity, while brite database provides more classification criteria.

4. With regard to the chemical structural changes between different drugs, there is a special category called Drug Development in the pathways database to record.

After reading the above, do you have any further understanding of how to analyze the KEGG Drug database? If you want to know more knowledge or related content, please follow the industry information channel, thank you for your support.

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