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Editor to share with you the DNA damage repair gene database example analysis, I believe that most people do not know much about it, so share this article for your reference, I hope you can learn a lot after reading this article, let's go to know it!

DNA damage and repair is an important phenomenon in life activities. According to statistics, each somatic cell is damaged by DNA at least 60, 000 times a day. It is precisely because of the existence of DNA damage repair mechanism that these injuries can be corrected and repaired at any time to ensure normal life activities.

If the DNA damage is not repaired correctly, the following three situations may occur

Cell senescence accelerates the process of cell senescence

Apoptosis, when the DNA damage is excessive and cannot be repaired, the apoptosis procedure will be initiated to remove the damaged cells.

In the case of cell canceration and partial repair of DNA damage, cells will have various genomic mutations, which accumulate to a certain extent, causing normal cells to turn into tumor cells.

DNA damage and repair mechanisms play an important role in maintaining normal life activities and tumorigenesis and development. Through the unremitting efforts of scientists, we have a clearer understanding of DNA damage repair mechanisms, mainly in the following categories

1. BER

The full name is Basic excision repair, called base excision repair, which is initiated by DNA glycosylase to identify deletion, mismatch, alkylation and other damage types, and can remove or replace a single damaged base.

2. NER

The full name is nucleotide excision repair, which is called nucleotide excision repair, which recognizes the abnormal double helix structure of DNA and repairs the damage of consecutive multiple bases.

3. MMR

The full name is mismatch excision repair, which is called mismatch excision repair, which is used to correct base mismatch, insertion, deletion and other DNA damage caused by various reasons.

4. Double strand break repair

The breakage of DNA double strand will lead to the loss and rearrangement of genomic sequence, which is the most serious DNA damage. This kind of damage is mainly repaired by homologous recombination to repair HR and non-homologous terminal link repair NHEJ.

When annotating tumor mutations, oncotator specifically integrates the data of a damage repair gene, and summarizes the DNA damage repair related genes mentioned by Wood RD et al.

Https://www.mdanderson.org/documents/Labs/Wood-Laboratory/human-dna-repair-genes.html

The corresponding gene name, category, chromosome location and other detailed information are given. If we pay attention to the relationship between DNA damage repair and tumor mutation, this database is worth referring to.

The above is all the contents of the article "sample Analysis of DNA damage repair Gene Database". Thank you for reading! I believe we all have a certain understanding, hope to share the content to help you, if you want to learn more knowledge, welcome to follow the industry information channel!

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