Shulou(Shulou.com)06/01 Report--

This article will explain in detail what is the use of The Cancer Immunome Atlas database. Xiaobian thinks it is quite practical, so share it with you as a reference. I hope you can gain something after reading this article.

Tumor immunotherapy has achieved remarkable results in the clinical treatment of many malignant tumors, but there is still a problem that most patients do not respond to immunotherapy. To better understand tumor-immune cell interactions, the scientists analyzed NGS data from TCGA and several other large cancer research programs for 20 solid tumors.

https://linkinghub.elsevier.com/retrieve/pii/S2211124716317090

In order to better view the analysis results, the relevant data will be organized into a database, the website is as follows

https://tcia.at/

Click on the histogram corresponding to each tumor to view the specific data. Take BRCA for example, the results are as follows

1. Patients list

The ID, gender, age and other information of each tumor patient are listed as follows

Click on the patient ID to view detailed clinical information, as shown below

2. Gene Expression

The following 3 results are provided for the expression amount of the gene

gene expression boxplots

gene expression heatmaps

survival analysis

the results are indicated as follows

3. Cell type Fractions

qyanTIseq and Cibersort software were used to analyze the immune cell components of tumor patients. The results are shown as follows

4. GSEA

To analyze whether immune cells are enriched in a particular tumor, the results are as follows

5. Heterogeneity

The heterogeneity of different tumor patients was analyzed, and the results are shown as follows

6. Neoantigens

Analysis of tumor neoantigens, the results are shown below

The database can not only view the analysis results of different tumors in TCGA, but also its analysis content is worth learning from. For the NGS data of tumor samples, it can carry out association analysis between gene expression and survival analysis, immune cell infiltration analysis, new antigen prediction and other analysis contents.

About "What is the use of The Cancer Immunome Atlas database" this article is shared here, I hope the above content can be of some help to everyone, so that you can learn more knowledge, if you think the article is good, please share it for more people to see.

Welcome to subscribe "Shulou Technology Information " to get latest news, interesting things and hot topics in the IT industry, and controls the hottest and latest Internet news, technology news and IT industry trends.