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This article mainly introduces what Epifactors is a database, has a certain reference value, interested friends can refer to, I hope you can learn a lot after reading this article, the following let the editor take you to understand it.

The research on epigenetic marker molecules such as DNA methylation histone modification and chromatin remodeling has developed rapidly and a great deal of knowledge has been accumulated in related fields. By sorting and summarizing the corresponding genes and functions of the proteins involved in these epigenetic mechanisms, the Epifactors database is constructed at the following website

Http://epifactors.autosome.ru/

In order to provide more comprehensive and rich cognition, on the basis of the traditional proteins directly involved in epigenetics, the concept of epigenetic factors is defined, which connects the core proteins directly involved in epigenetics with their surrounding proteins. it further enriches the network structure of related molecules in epigenetics.

The following proteins are defined as apparent factors.

Proteins acting as histones, histone variants or protamines

Proteins performing post-translational modifications of histones or recognizing such modifications (histone modification 'writers',' erasers' or 'readers')

Proteins changing the general structure of chromatin (performing chromatin remodeling), including Proteins that move, eject or restructure nucleosomes (ATP-dependent chromatin remodelers) and proteins that incorporate histone variants into the nucleosomes.

Proteins assisting histone folding and assembly

Proteins acting upon modifications of DNA or RNA in such a way that it affects gene expression, but not through RNA processing

Protein cofactors forming complexes with epigenetic factors, where complex formation is important for the activity.

The genes, proteins, products and protein complexes corresponding to these factors are annotated in detail, providing a more complete information chain. The functions of apparent factors are classified, and the number of factors related to several main functions is as follows.

The official website provides the following three types of retrieval and viewing methods

Genes

Complexes

Histones and Protamines

Taking Genes as an example, the results are as follows

We can see the information of gene symbol, protein ID, domain, function, protein complex, regulatory target molecule and so on.

At the same time, some factors also provide the data of expression in different cell lines and tissues, as shown below.

The information in the database is downloaded free of charge, as shown below

This database is a very valuable database for researchers in the field of epigenetics, which can quickly have a complete understanding of the function of an epigenetic factor.

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