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IARC TP53 database example analysis, many novices are not very clear about this, in order to help you solve this problem, the following editor will explain for you in detail, people with this need can come to learn, I hope you can gain something.

TP53 gene, also known as p53, is a tumor suppressor gene, which encodes a protein with molecular weight of 53KDa, mediates the process of apoptosis, and achieves tumor inhibition by mediating the process of apoptosis of cancer cells. As the most prone to mutation and the most important tumor suppressor gene, the study of TP53 gene-related mutation is very comprehensive and in-depth. IARC TP53 database collects and collates the mutations in TP53 gene published in literature and in public databases. The database website is as follows.

Http://p53.iarc.fr/Scope.aspx

The database contains the following TP53 gene-related variation information.

Somatic mutations in cancer samples

Germline mutations in normal samples of cancer patients, family members and controls

Common TP53 polymorphic loci in human

Functional rating of TP53 mutant protein

Mutation information of TP53 gene in different cell lines

Mutation Information of TP53 Gene in Mouse Model

Mutations supported by experimental evidence

At the same time, it also includes the clinicopathological information, survival data and other related information of tumor patients. The retrieval system of the customs clearance official website can retrieve data flexibly, and the most basic retrieval method is to use the description information of the mutation site, as shown below.

You can enter one or more different levels of mutation description information for retrieval. Take C.524G > An as an example, the search results are as follows

The corresponding descriptions of genomic, cDNA, protein3, exon position, functional influence, and links to clinvar, cosmic, dbsnp, genomeAD and other databases are given. In addition, it can also be searched according to the different characteristics of the mutation site, as shown below

It can be searched according to the type of base mutation, exon, whether the mutation is harmful, chromosome position and other conditions. the table form of the search result is the same as the first search result. For multiple search results, the mutation characteristics and distribution in different tumors can be seen.

1. Mutation distribution

View the distribution of the following two types of information

Mutation type

Mutation effects

The results of Mutation type are as follows

The results of Mutation effects are as follows

2. Tumor distribution

Look at the distribution of somatic mutations and germline mutations on various tumors, and the results are shown in a bar chart, as shown below

If there is a need for in-depth study of TP53 gene-related mutations, this database is very worthy of reference.

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