Shulou(Shulou.com)06/01 Report--

What is the regulation mechanism of ceRNA? in view of this problem, this article introduces the corresponding analysis and solution in detail, hoping to help more partners who want to solve this problem to find a more simple and feasible method.

The full name of ceRNA is competing endogenouse RNA, and it is called competitive internal RNA in Chinese. Different from the concepts such as ncRNA, ceRNA does not represent a specific type of RNA, but a regulatory mechanism.

In the concept of ceRNA, there are two key words, competition and endogenous, which means that this regulatory mechanism already exists in organisms, and competition is the core of this regulatory mechanism.

MiRNA can bind to the target mRNA, inhibit its translation or lead to mRNA degradation, thus realizing the function of post-transcriptional regulation of gene expression. In the combination mechanism of miRNA and mRNA, there is a concept called MREs (microRNA response elements), which is called miRNA response element in Chinese. It is precisely because there is a related MREs on mRNA that it can be combined with miRNA.

With the deepening of transcriptome research, it is found that there is not only MRE on mRNA, but also MRE on other types of RNA, such as lncRNA,pseudogene, circRNA, etc., which means that the same miRNA can bind to multiple, multiple types of RNA, and a competitive relationship is formed between RNA molecules that bind to the same miRNA.

Based on the theory of RNA molecule, the negative regulation target of miRNA, scientists proposed a model of ceRNA regulation mechanism, which is illustrated as follows.

In the image above, RNA X and RNA Y form a ceRNA regulatory relationship by binding the same miRNA. In the case of cell homeostasis, the miRNA bound by X and Y forms a balance. When the expression of Y is down-regulated, the bound miRNA becomes less, resulting in more miRNA binding to X, resulting in a decrease in the expression of X. Similarly, when the expression of Y increases, more miRNA binds to Y, resulting in less miRNA bound to X, and the expression of X increases when the negative regulation becomes weaker.

From the above model, we can see that there are two key points in the ceRNA regulation mechanism. First, the miRNA that the two RNA molecules can bind must intersect, which is the only way to form a competitive relationship. Secondly, the expression of the RNA molecule that constitutes the ceRNA regulation relationship is a positive correlation.

CeRNA can be regarded as a kind of balance, when the balance is broken, it will lead to the disorder of life activities, the emergence of various abnormal shapes, the occurrence of diseases and so on, especially in the research field of tumors and other complex diseases, the research on the regulation mechanism of ceRNA is also a hot spot.

This is the answer to the question about the regulation and control mechanism of ceRNA. I hope the above content can be of some help to you. If you still have a lot of doubts to be solved, you can follow the industry information channel to learn more about it.

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