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In the study of DNA methylation and disease, one of the most common questions is whether there is published literature showing that a gene has been methylated in a disease. Answering such questions requires a lot of document retrieval work.

PubMeth collects and collates cancer-related methylation data in the literature, proofread and annotates manually, and provides a high-quality database of cancer-related methylation genes.

The web address is as follows

Http://www.pubmeth.org/

This database only provides online retrieval function and is not open for download. When searching, two retrieval methods are provided:

genes

cancer

A total of 292 human genes were recorded in PubMeth database.

Http://pubmeth.biobix.be/temp/static/

For each gene, there is relevant literature and cancer type information. Take CDKN2A as an example

Quantitative distribution of literature related to different cancers

Quantitative distribution and methylation frequency of different cancer-related literatures

In addition to the overall distribution, more specific information is given about the gene in each type of cancer. For example, the methylation information of CDKN2A gene in lung cancer

Http://pubmeth.biobix.be/temp/static/CDKN2A_lung.html

Using cancer as the keyword to search, I tried several times, probably because of the network, but all of them were unsuccessful.

Using this database, we can reduce the workload of literature retrieval and conduct a survey on the methylation of a gene or a disease in advance.

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