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What are the naming conventions of miRNA? for this question, this article introduces the corresponding analysis and answer in detail, hoping to help more partners who want to solve this problem to find a more simple and feasible way.

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The research of miRNA started very early, and the earliest miRNA discovered were let-7 and lin-4 in nematodes. As more and more miRNA were discovered, in order to facilitate academic exchanges, some scientists proposed a set of unified naming conventions. The corresponding literature is as follows.

A uniform system for microRNA annotation

Ambros, Victor, et al. 3, 2003, RNA, Vol. 9, pp.

The specification in this document is mainly used to provide a unified name for the newly discovered miRNA. For the miRNA previously discovered and given its name in the literature, it still retains its original name, such as hsa-let-7. The name of a typical mature miRNA is as follows.

Hsa-miR-1290

It can be thought of as consisting of three fields separated by -. The first three-letter abbreviation indicates the species from which the miRNA originated, such as hsa for human and mmu for mouse;. The second field is miR, representing the mature miRNA; third field digit, representing the order in which miRNA is discovered.

For miRNA precursors, you only need to replace miR with mir. For example, hsa-mir-1290; is represented by the suffixes of-5p and-3p for two mature miRNA from the same miRNA precursor, such as hsa-miR-12-5p and hsa-miR-12-3p.

Two miRNA with high homology are distinguished by lowercase letters a, b, etc. For example, hsa-miR-5a and hsa-miR-5b; are distinguished by adding numeric suffixes to the identical miRNA compiled by different genes, such as hsa-miR-1290-1 and hsa-miR-1290-2.

These are the basic rules of miRNA naming.

MiRBase database is the most basic reference database for miRNA research. In this database, miRNA precursors are represented by mir plus numbers, and numbers are represented by MI, such as hsa-mir-122, MI00042; mature miRNA is represented by miR plus digital identification, and numbers are represented by MIMAT. For example, hsa-miR-122-5p corresponds to MIMAT000421.

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The answers to the questions about miRNA naming conventions are shared here. I hope the above content can be of some help to you. If you still have a lot of doubts to be solved, you can follow the industry information channel for more related knowledge.

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