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This article mainly shows you "what is the use of HLA Epitope Registry-HLA antigen epitope database". It is easy to understand and clear. I hope it can help you solve your doubts. Let me lead you to study and learn this article "what is the use of HLA Epitope Registry-HLA antigen epitope database?"

Antigenic epitopes refer to the special chemical genes that determine the specificity of antigens in antigenic molecules. Antigens want to bind to the corresponding antigenic receptors through antigenic epitopes, thus causing immune response. An antigenic molecule can contain multiple antigenic epitopes. The nature, number and spatial structure of antigenic epitopes determine the specificity of antigens.

There are common antigenic epitopes among a variety of antigenic molecules, and the antibodies produced by stimulating the body by these common antigenic epitopes can bind to a variety of antigenic molecules, which is called cross-reaction.

When using conventional serological methods to type HLA, it can not specifically identify a certain antigen due to the existence of cross-reaction, so the result of serological typing corresponds to the collection of multiple antigens. In order to understand the specificity of HLA antigen, it is necessary to study its epitopes. HLA Epitope Registry is an online database that stores the information of antigenic epitopes corresponding to HLA Allel.

The website is as follows:

Http://epregistry.ufpi.br/

For different HLA loci, different sub-databases are used to store them. There are several sub-databases.

ABC

DRB

DQB+DQA

DPB + DPA

MICA

Take ABC as an example. The database stores the antigenic epitope information of three classic HLA type I genes, HLA-A, HLA-B and HLA-C. The website is as follows.

Http://epregistry.ufpi.br/index/databases/database/ABC/

The first column is the name of the antigen epitope, the second column represents whether the group is exposed on the surface of the antigen molecule, the third column of information is the same as the first column, the fourth column represents the frequency, and the fifth column represents the antibody reaction. If there is experimental evidence to support it, the value is confirmed, the other column is provisional; column 6 represents the structure of the antigen epitope, and the seventh column represents the corresponding HLA Allel in the Luminex chip. The eighth column represents all the Allel corresponding to the epitope.

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