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This article is to share with you about the RNA secondary structure representation Dot-Bracket notation how to understand, the editor feels very practical, so share with you to learn, I hope you can get something after reading this article, do not say much, follow the editor to have a look.

For the predicted novel miRNA, that is, the new miRNA, we will want to know its secondary structure. For the secondary structure of RNA, the most intuitive representation must be a picture, as shown below

The image above shows a precursor of miRNA, or pri-miRNA, with a typical stem-loop structure, except that the other bases are complementary.

The picture is particularly intuitive to the analyst, but it is not recognizable to the software. In order to make the program recognize the secondary structure of RNA, a special representation is developed, which uses two symbols, period and parentheses, to represent the corresponding secondary structure.

This representation is called dot-bracket notation, and its core idea is to use paired parentheses to represent complementary base pairs, continuous dots to represent stem-ring structure, and for the secondary structure shown in the following figure.

The corresponding expression is as follows

((). ()

Starting with the base corresponding to the first black dot, there are three paired bases at first, so use three first, followed by two unpaired bases in the stem-ring structure, with two. Indicates that there are four paired bases, then three unpaired bases, and then the subsequent paired bases are represented by the first left parenthesis (the base is paired, so it is indicated by the right parenthesis).

This representation uses only two symbols, and both of them can be recognized by the computer, so the software can also recognize them. In many software and databases, the secondary structure given will be represented in this way.

The above is how to understand the RNA secondary structure representation Dot-Bracket notation. The editor believes that there are some knowledge points that we may see or use in our daily work. I hope you can learn more from this article. For more details, please follow the industry information channel.

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