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This article mainly shows you "what is the use of LncACTdb database", the content is easy to understand, clear, hope to help you solve your doubts, the following let the editor lead you to study and learn "what is the use of LncACTdb database" this article.

CeRNA is a very hot regulatory mechanism studied in recent years, which refers to the competitive binding of different RNA molecules to miRNA, through this competitive relationship to regulate the expression of different RNA, where RNA molecules can be mRNA, lncRNA, or even pseudogene.

LncATCdb database records disease-related lncRNA-miRNA-mRNA ceRNA network data, and provides the results of functional enrichment analysis, network map visualization, survival analysis, etc.

Http://www.bio-bigdata.net/LncACTdb/index.html

The content in the database is divided into the following two parts

Predicted data

Experimental data

Software prediction can be divided into two categories: software prediction and experimental verification. Software prediction refers to the use of software such as miRanda to predict the interaction of lncRNA-miRNA, and then to analyze ceRNA;, while experimental verification is mainly the ceRNA information collated from the literature.

Taking the results predicted by the software as an example, the retrieval results are as follows

Click Detail to view details, including the following information

1. Basic information

The names of the various ceRNA analyses, related diseases and other information that make up the RNA regulatory network are shown below

In addition, the detailed results of the interaction between lncRNA-miRNA and mRNA-miRNA are also included. The interaction between lncRNA and miRNA is predicted using several softwares in the figure below

The interaction of mRNA-miRNA is obtained from the database, as shown below

2. CeRNA Network Visualization

The results are as follows: the ring layout is used to show the lncRNA and mRNA that make up the ceRNA relationship. Because of the large number of miRNA combined with the two, the miRNA is not shown in the figure.

3. Functional enrichment

The protein coding genes that form the ceRNA relationship with lncRNA were analyzed by GO and KEGG. The results are as follows.

4. Disease marker

5. Survival analysis

For all kinds of RNA molecules in ceRNA network, the data in TCGA database are used to analyze the survival of the disease. the results are as follows.

In addition, the database also provides an online tool, lncACT-Get, which can upload its own expression profile data and then conduct ceRNA analysis.

The information in the database is free to download and provides the following eight types of information

The contents of the ceRNA files supported by the experimental evidence are as follows

Through this database, we can get the existing ceRNA relationship, and more conveniently, because the interaction between lncRNA-miRNA and mRNA-miRNA has been stored in the database, we can upload our own expression profile data and identify the new ceRNA network through online tools.

The above is all the contents of the article "what is the use of LncACTdb database". Thank you for reading! I believe we all have a certain understanding, hope to share the content to help you, if you want to learn more knowledge, welcome to follow the industry information channel!

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