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Editor to share with you what is the use of DiseaseMeth database, I hope you will gain something after reading this article, let's discuss it together!

As an epigenetic marker, DNA methylation plays an important role in growth and development and disease occurrence. With the progress of large-scale methylation research, a large number of disease-related methylation data have been accumulated. DiseaseMeth is a database that keeps methylation information related to human diseases.

The official website address is as follows

Http://bio-bigdata.hrbmu.edu.cn/diseasemeth/

In the DiseaseMeth database, the types of methylation data include two major categories

Chip

For DNA methylation chips, in addition to the two common illuminaDNA methylation chips, 27K and 450K, there are other customized chips, such as illumina GoldenGate Methylation Cancer Panel I.

NGS

High-throughput sequencing mainly includes two kinds of data: WGBS and RRBS.

The detailed information is as follows:

Array-based mainly includes 27K and 450K, of which 27K is 8.6, 450K is 9.3 ngs based mainly includes WGBS and RRBS,WGBS is 3.9 and RRBS is 4.3.

For diseases, there are seven types:

Cancer

Genetic Disorder

Metabolic Disorder

Autoimmune Disease

Neurolobical Disease

Imflammation

Others

Among them, Cancer has the most data. The details are as follows:

Using this database, we can retrieve relevant information according to diseases or genes. Taking the gene DEFB119 as an example, the search results of the gene-related diseases are as follows

From the search results, we can get the disease associated with the gene, and whether the methylation level of the gene increases or decreases in the disease.

For related diseases, heat map data can also be downloaded.

Through this database, we can retrieve the results of existing studies on the methylation of a disease or a gene.

After reading this article, I believe you have a certain understanding of "what is the use of DiseaseMeth database". If you want to know more about it, you are welcome to follow the industry information channel. Thank you for reading!

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